Introduction
Patients with infective endocarditis on the left side of the heart are
This report describes nine patients with endocarditis treated with linezolid and 33 similar cases
Linezolid is an oxazolidinone with an effect on Gram-positive cocci
This report describes nine patients with endocarditis treated with linezolid and 33 similar cases from the medical literature
Linezolid is active against a wide range of Gram-positive bacteria and has been generally available for the treatment of Gram-positive infections since 2000
The compound is a synthetic antibiotic that inhibits bacterial protein synthesis through binding to rRNA
Linezolid may be substituted for penicillin or ceftriaxone if the patient has a history of severe, immediate penicillin hypersensitivity, such as urticaria Less than 7 days, gestational age at least 34 weeks: 10 mg/kg orally every 8 hours
This report describes nine patients with endocarditis treated with linezolid and 33 similar cases from the medical literature
Only a few casuistic reports describe its utilization in the treatment of IE
Although Enterococcus faecalis and Enterococcus faecium are the 2 most clinically relevant species, E
Yet, it is also the fourth most common life-threatening infection after sepsis, pneumonia, and intraabdominal abscess, with an estimated inpatient mortality rate between 15 to 30%
Linezolid is a bacteriostatic agent and so we cannot recommend it as monotherapy
Treatment regimens included beta-lactams, linezolid, fluoroquinolones, trimethoprim-sulfamethoxazole, or clindamycin, with or without rifampin
To the best of our knowledge, none of these patients had endocarditis or other sequelae
Linezolid was widely used for the treatment of complicated skin and soft tissue infection, pneumonia, endocarditis and bacteremia etc
Moreover, changes in pathogen prevalence,in particular a more common
Although not inclusive of bacterial endocarditis, several of the trials included in this review included bacteremia in either primary or subgroup analyses of linezolid vs a comparator bactericidal agent
It is indicated for gram-positive infections and approved for the treatment of bacterial pneumonia, skin and skin structure infections, and vancomycin-resistant enterococcal (VRE) infections, including infections complicated by bacteremia
Linezolid for endocarditis: a case series of 14 patients