Endocrine therapy, targeted therapy, cytotoxic chemotherapy and radiotherapy are the most commonly used therapeutic strategies for breast cancer patients, and they can be
To clarify the incidence and risk factors of infusion-related reactions (IRRs) caused by trastuzumab in breast cancer patients and verify the preventive effects of dexamethasone
Anthracycline and cyclophosphamide are generally used for patients with breast cancer in neoadjuvant, adjuvant, or Incidence of infusion hypersensitivity reaction after withholding dexamethasone premedication in early breast cancer patients not experiencing two previous cycles of infusion hypersensitivity reaction for weekly paclitaxel chemotherapy
In contrast, posttreatment with dexamethasone had no protective effects
Int J Oncol 2007 This study established a semi-mechanism-based PK/PD model for characterizing the time-dependent pharmacokinetics of DEX and its anti-cancer effect in breast cancer xenograft mice
1) Renal Failure: Monitor renal function prior to treatment and periodically thereafter
There is substantial pre-clinical data to support that Dex activation of the glucocorticoid receptor overrides chemotherapy-induced apoptosis in breast cancer cell
Depending on the serum calcium levels, hypercalcemia is categorized either as mild when the calcium levels are between 10 to 12 mg/dL, moderate when the levels are between 12 to 14 mg/dL, or severe when the levels are more than 14 mg/dL
6
58 A large confirmatory trial is ongoing